Summary: In the last decade, concerns about the possible use of chemical and biological weapons in both military and civilian settings has prompted Congress and federal agencies to launch new programs or expand existing ones to address these threats. Overall funding in these areas has risen significantly since 1996. Today, several civilian and military agencies are conducting research and development to counter these threats. Without effective coordination among the different agencies, however, their efforts might be unnecessarily duplicated and important questions may be overlooked. This testimony identifies similarities among nonmedical research and development programs and explains how coordination mechanisms could effectively address potential duplication, research gaps, and opportunities for collaboration. GAO focuses on the following four programs: (1) the Defense Department's Chemical and Biological Defense Program, (2) the Defense Advanced Research Projects Agency's Biological Warfare Defense Program, (3) the Department of Energy's Chemical and Biological Nonproliferation Program, and (4) the Counterterror Technical Support Program conducted by an interagency working group.